A guide to oligonucleotide chemistry
What oligonucleotides are, how DNA and RNA are built from nucleotides, and why the phosphodiester backbone matters for the medicines being designed on Syngenis One.
8 min read
Read guideGuides
Long form guides to nucleic acid science.
Explainers on the chemistry, design and application of RNA and DNA, written by our chemists for researchers and the next generation of RNA innovators.
All guidesFundamentals Modalities Design Chemistry Manufacturing
Explainers from our chemists
Antisense oligonucleotides explained
How antisense oligonucleotides silence or reshape a gene's message, the difference between gapmers and splice switchers, and the chemistry that makes them work in patients.
9 min read
Read guidesiRNA design principles
How small interfering RNAs use the cell's own RNA interference machinery, what makes one siRNA more potent and specific than another, and how GalNAc delivery reaches the liver.
10 min read
Read guideChemical modifications: a field guide
The modifications that turn a fragile strand into a medicine: phosphorothioate backbones, two prime sugar chemistries, locked nucleic acids and morpholinos, and when to reach for each.
11 min read
Read guideFrom design to delivered oligo
What actually happens between ordering an oligo and receiving it: solid phase synthesis, scale and yield, purification choices, and the quality control that proves you got what you ordered.
7 min read
Read guidePut it into practice
Design your candidate on Syngenis One
Take these principles from theory to a synthesis ready oligo in one guided workflow.
One Platform. Six Connected Pillars.
One engine, working across the whole business.
Syngenis One (AI Discovery)
Design RNA and DNA candidates from target to synthesis ready oligo in one workflow.
Manufacturing
Australia's only commercial RNA facility. Custom oligonucleotides, ordered through Syngenis One.
Research and Diagnostics
AI led therapeutic programs and an aptamer based diagnostics pipeline.
Clinical
A specialist nucleic acid CRO with in silico trial modelling.
Life Care
Consumer genomics at a mass market price.
Fund
Infrastructure that channels research investment into the pipeline.