A guide to oligonucleotide chemistry
What oligonucleotides are, how DNA and RNA are built from nucleotides, and why the phosphodiester backbone matters for the medicines being designed on Syngenis One.
8 min read
Read guideKnowledge Hub
Guides, calculators and reference for nucleic acid science.
Guides, calculators and a glossary for the science behind RNA and DNA medicine.
Knowledge Hub
Australia's most comprehensive resource on oligonucleotide chemistry.
Built by our chemists for researchers, designers and the next generation of RNA innovators. Explore long form guides, interactive calculators, a glossary of the field and a curated library of the papers that built it. The hub is both a genuine resource for the field and the way new researchers discover Syngenis.
Calculators
Interactive tools for everyday design and property calculations, connected to Syngenis One.
Open the calculatorsLiterature
A curated library of the landmark papers behind RNA and DNA medicine, each with a plain language summary.
Explore the libraryFeatured guidesFundamentals Modalities Design Chemistry
Start here
Antisense oligonucleotides explained
How antisense oligonucleotides silence or reshape a gene's message, the difference between gapmers and splice switchers, and the chemistry that makes them work in patients.
9 min read
Read guidesiRNA design principles
How small interfering RNAs use the cell's own RNA interference machinery, what makes one siRNA more potent and specific than another, and how GalNAc delivery reaches the liver.
10 min read
Read guideChemical modifications: a field guide
The modifications that turn a fragile strand into a medicine: phosphorothioate backbones, two prime sugar chemistries, locked nucleic acids and morpholinos, and when to reach for each.
11 min read
Read guideDesign calculators
Interactive tools
Oligo properties calculator
Paste a DNA or RNA sequence and instantly see length, GC content, melting temperature, molecular weight, extinction coefficient and OD conversions.
Resuspension calculator
Work out how much buffer to add to a lyophilised oligo to reach the stock concentration you want, in micromolar or nanograms per microlitre.
Work with us
Explore the Knowledge Hub
Built by our chemists for researchers, designers and the next generation of RNA innovators. New guides, calculators and references are added over time.
One Platform. Six Connected Pillars.
One engine, working across the whole business.
Syngenis One (AI Discovery)
Design RNA and DNA candidates from target to synthesis ready oligo in one workflow.
Manufacturing
Australia's only commercial RNA facility. Custom oligonucleotides, ordered through Syngenis One.
Research and Diagnostics
AI led therapeutic programs and an aptamer based diagnostics pipeline.
Clinical
A specialist nucleic acid CRO with in silico trial modelling.
Life Care
Consumer genomics at a mass market price.
Fund
Infrastructure that channels research investment into the pipeline.