Custom DNA and RNA oligonucleotides, built to order, delivered from Australia.
Australia's only commercial RNA manufacturing facility, producing custom oligonucleotides for research, diagnostics and clinical supply.
The commercial base of Syngenis.
Manufacturing is the commercial base of Syngenis and a major pillar in its own right. We manufacture custom synthetic DNA and RNA oligonucleotides for customers across research, diagnostics and early development, and we are extending into regulated, human grade supply. Manufacturing is our main entry point for customers and the foundation on which the rest of the platform is built. Customers engage Syngenis for reliable, repeat production and order through the Syngenis One system, our online quoting and ordering platform.
A standalone division, and a large market.
Demand for custom DNA and RNA is substantial and growing quickly, driven by the rise of RNA medicine, molecular diagnostics and genomics. Yet local, regulated capability in Australia and the wider Asia Pacific region remains limited, leaving developers dependent on offshore supply with long lead times and complex logistics. Syngenis manufactures on home soil, giving local and regional customers an onshore alternative, and can supply customers anywhere.
What we make.
- Antisense oligonucleotides and siRNA, standard and modified.
- microRNA and antimiR constructs, guide RNA for CRISPR applications.
- DNA probes, primers and molecular beacons.
- Aptamers for research and diagnostics.
- Specialty chemistries, including phosphorodiamidate morpholino oligomers (PMOs).
See the full catalogue of chemistries, linkages, modifications and conjugations on the Products and Chemistries page.
Research grade, available now.
Our GLP research grade facility is operational and generating revenue today, supplying custom oligonucleotides for research, diagnostics and early development, supported by specialised synthesis and analytical equipment, established quality systems and an experienced technical team. Research grade supply provides recurring revenue, close technical interaction with customers, and early visibility into programs that may progress toward regulated use. It is the main entry point for customers and supports long term, repeat engagement.
Clinical grade, in build.
Alongside the research grade laboratory, we are building a GMP, human grade DNA and RNA manufacturing facility for regulated diagnostic, clinical trial and approved human use, targeted for 2027. GMP manufacturing requires higher standards of quality control, documentation, traceability and oversight than research grade supply, and the facility has been designed as a flexible, human grade environment able to support a range of regulated applications. When complete, Syngenis expects this to be one of the only domestic GMP oligonucleotide manufacturing facilities of its kind in Australia.
Chemistries only a few can make.
Some chemistries are far more complex to make than standard oligonucleotides and are produced by only a small number of manufacturers globally. PMOs are one example, used in advanced therapeutic and selected diagnostic applications and sitting behind high regulatory and operational barriers. Establishing this capability in Australia would give local developers domestic access to chemistries currently sourced almost entirely from overseas, a highly differentiated position with limited direct competition.
Order through the Syngenis One system.
Customers upload custom DNA or RNA sequences, receive an immediate quotation, place orders and track production through the Syngenis One system. It fully supports DNA and RNA design, validation and ordering, with transparent pricing and full traceability, and connects customers directly with our technical teams.
Ready to work with an integrated life sciences company?
Talk to our team about your program, from candidate design to trial ready material.
One engine, working across the whole business.
Syngenis One (AI Discovery)
Design RNA and DNA candidates from target to synthesis ready oligo in one workflow.
Manufacturing
Australia's only commercial RNA facility. Custom oligonucleotides, ordered through Syngenis One.
Research and Diagnostics
AI led therapeutic programs and an aptamer based diagnostics pipeline.
Clinical
A specialist nucleic acid CRO with in silico trial modelling.
Life Care
Consumer genomics at a mass market price.
Fund
Infrastructure that channels research investment into the pipeline.