The medicinal chemistry of therapeutic oligonucleotides
Wan WB, Seth PP · Journal of Medicinal Chemistry, 2016
Wan WB, Seth PP
A detailed survey of the chemical modifications that turn a fragile strand into a medicine. It compares backbone changes, two prime sugar modifications, bicyclic nucleic acids and conjugation strategies, and explains how each affects stability, affinity, potency and safety. An essential reference for designing the modification pattern of an oligonucleotide.
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