GalNAc conjugate (N acetylgalactosamine)
A sugar tag that directs an oligo to liver cells after a simple injection.
GalNAc, short for N acetylgalactosamine, is a sugar that binds a receptor found almost exclusively on liver cells. Attaching GalNAc to an oligonucleotide lets the liver take it up efficiently after a simple subcutaneous injection.
GalNAc conjugation is the delivery breakthrough behind most approved siRNA drugs, and extending targeted delivery beyond the liver is an active frontier.
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