Gapmer
An antisense oligo with a DNA core and modified wings, designed so RNase H cuts the target.
A gapmer is an antisense oligonucleotide built with a central window of unmodified DNA flanked by chemically modified wings. The DNA gap allows the enzyme RNase H to recognise the bound duplex and cut the target messenger RNA, while the wings protect the ends and increase binding strength.
Balancing the size of the gap against the modification of the wings is a central design decision for silencing ASOs.
Design with these concepts on Syngenis One
Our platform puts the chemistry behind these terms to work, from candidate design to synthesis ready oligo.
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Syngenis One (AI Discovery)
Design RNA and DNA candidates from target to synthesis ready oligo in one workflow.
Manufacturing
Australia's only commercial RNA facility. Custom oligonucleotides, ordered through Syngenis One.
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AI led therapeutic programs and an aptamer based diagnostics pipeline.
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A specialist nucleic acid CRO with in silico trial modelling.
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Consumer genomics at a mass market price.
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Infrastructure that channels research investment into the pipeline.