Two prime O methyl (2'-OMe)
A naturally occurring sugar modification that improves stability and lowers immune stimulation.
Two prime O methyl is a modification that adds a methyl group to the two prime position of the ribose sugar. It occurs naturally in the body, increases resistance to nucleases and binding affinity, and reduces immune stimulation.
It is widely used in the wings of gapmer ASOs and throughout siRNA duplexes.
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