In vitro selection of RNA molecules that bind specific ligands
Ellington AD, Szostak JW · Nature, 1990
Ellington AD, Szostak JW
The paper that introduced aptamers. Ellington and Szostak showed that specific RNA molecules can be selected from a vast random library to bind a chosen target, coining the term aptamer. This in vitro selection idea, later called SELEX, underpins aptamer based diagnostics and therapeutics, including the Syngenis aptamer diagnostics pipeline.
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